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Meselson, Stahl, and the Replication of DNA: A History of 'The Most Beautiful Experiment in Biology', by Frederic Lawrence Holmes
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In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment.
- Sales Rank: #1899645 in Books
- Published on: 2001-11-15
- Original language: English
- Number of items: 1
- Dimensions: 11.64" h x 1.38" w x 5.38" l, 1.94 pounds
- Binding: Hardcover
- 503 pages
Review
"Holmes has written a remarkable history of one of molecular biology's most significant experiments." -- David Baltimore, president, California Institute of Technology
"Holmes meticulously shows how science is done." -- Alfred Tauber, Boston University
About the Author
The late Frederic Lawrence Holmes was Avalon Professor and chair for the Section of History of Medicine at Yale University. William C. Summers is professor of therapeutic radiology and molecular biophysics and biochemistry, as well as lecturer in history, at Yale University.
Most helpful customer reviews
3 of 3 people found the following review helpful.
How real science is done
By Serge Ledan
This is an excellent book for anyone interested in knowing how real science is done. Real science is not the clean, simple, easy process described in the media. It is tedious, untidy, difficult and it takes patience, determination and passion. This book conveys an intimate and close view of how real scientific biological reaearch is conducted.
4 of 4 people found the following review helpful.
A beautiful history of a beautiful experiment
By Robert Haselkorn
This is a quite remarkable history. Holmes spent decades doing the research for this book. Even though I know both principals quite well and lived through their careers following the publication of the famous work, I did not know the full story of the work leading up to the "beautiful experiment". Holmes does a fantastic job capturing the thoughts and feelings of the principals and the supporting cast of Max Delbruck, Jim Watson, Cy Leventhal and others. Holmes thinks deeply about the philosophy of science and does a good job of explaining, with retroactive interviews, the thought processes of Meselson and Stahl as they circled around and finally hit on the right way to do the big experiment. The only small element I thought missing was a speculation about the possible reasons the Nobel committee has failed for more than 50 years to recognize the significance of the experiment.
1 of 1 people found the following review helpful.
A totally gripping account of one scientific discovery
By howard phillips
This book is so absorbing that I read from chapter 2 to the end in two days. A fascinating account of the ways that research scientists worked in the days before government and big business took over. Heavy in parts (the biochemistry), but with the human aspects well attended to, the experimental methods well described and at the end a description of the way in which ground breaking research finds its way into the mainstream and then into education, losing more and more of the excitement and finally reduced to fact, presented without any reference to the individuals involved or the actual experiments.
My copy from Amazon came originally as a withdrawn book from the university library of a well known Northern England university, and had never been read!
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